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| 调节性T细胞在骨破坏中的作用 | |
| 引用本文： | 孙传菊,李霞,赵懿清,袁凤来,吴繁荣,陈飞虎. 调节性T细胞在骨破坏中的作用[J]. 中国药理学通报, 2011, 27(8): 1048-1050. DOI: 10.3969/j.issn.1001-1978.2011.08.004 |
| 作者姓名： | 孙传菊 李霞 赵懿清 袁凤来 吴繁荣 陈飞虎 |
| 作者单位： | 1. 南通大学第三附属医院药剂科,江苏,无锡,214041 2. 安徽医科大学药学院,安徽,合肥,230032 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 代谢性骨破坏疾病如关节炎、骨质疏松,临床主要表现为骨骼的功能障碍,由于其机制目前仍未完全阐明,临床缺乏有效的治疗方法。调节性T细胞(Tregs)是一群具有免疫抑制功能的T细胞亚群,在免疫系统中起重要作用,体外实验证实Tregs抑制破骨细胞(OC)的分化和功能。在动物模型中,进一步证实Tregs通过抑制破骨细胞的发生而阻断骨质破坏的发生。该文对有关Tregs在骨破坏中的作用最新进展作一综述,以增进对Tregs生物学功能和病理作用的了解。 |
| 关 键 词： | 调节性T细胞 骨吸收 关节炎 骨质疏松 破骨细胞 骨破坏 |
Role of regulatory T cells in mediating bone destruction |
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| SUN Chuan-Ju,LI Xia,ZHAO Yi-qing,YUAN Feng-lai,WU Fan-rong,CHEN Fei-hu. Role of regulatory T cells in mediating bone destruction[J]. Chinese Pharmacological Bulletin, 2011, 27(8): 1048-1050. DOI: 10.3969/j.issn.1001-1978.2011.08.004 | |
| Authors: | SUN Chuan-Ju LI Xia ZHAO Yi-qing YUAN Feng-lai WU Fan-rong CHEN Fei-hu |
| Affiliation: | 1.Dept of Pharmacy,the Third Hospital Affiliated to Nantong University,Wuxi Jiangsu 214041,China; 2.Dept of Pharmacology,Anhui Medical University,Hefei 230032,China) |
| Abstract: | Metabolic bone diseases,such as rheumatoid arthritis(RA) and osteoporosis,cause long-term pain and disability.Effective clinical treatment for bone loss is in lacking because the knowledge of molecular mechanisms is understood incompletely.Recently,it has been confirmed that regulatory T cells(Tregs) play a crucial role in suppressing the immune response in the pathogenesis of various autoimmune diseases.In vitro,Tregs directly inhibit the differentiation and function of osteoclasts(OC).In animal model,it has been certified that Tregs block the destruction of bone through inhibiting OC.This article briefly introduces discuss the biological features of Tregs and summarizes recent advances in the role of Tregs in the pathogenesis and treatment of bone loss. |
| Keywords: | regulatory T cells bone loss rheumatoid arthritis osteoporosis osteoclasts bone destruction |
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