Incidence and Prognostic Significance of Proteinuria in Patients with Gastric Carcinoma

Incidence and prognostic significance of proteinuria in patients with gastric carcinoma

OBJECTIVE The present study was designed to evaluate the epidemiological and prognostic significance of proteinuria in patients with gastric cancer (GC).METHODS We retrospectively reviewed the frequency of proteinuria in patients with GC and analyzed its relationship with the GC biological characteristics, treatment and survival.RESULTS Proteinuria incidence in GC patients was 24.06%, which was significantly higher than that found in a control group (P＜0.01); the frequency of proteinuria was significantly correlated with an advanced disease stage(P＜0.01). We also found that the post-treatment mean value of proteinuria was remarkably lower than the pre-treatment value (P＜0.001). KaplanMeier analysis revealed a significant correlation between proteinuria and survival of GC patients (P＜0.05). Multivariate analysis demonstrated that the TNM stage, lymph node status and proteinuria may serve as independent prognostic markers in patients with GC (P ＜0.01).CONCLUSION A high prevalence of increased urinary protein excretion was observed in GC patients complicated with nephritis. Proteinuria may be used as one of the prognostic markers for patients with GC.