四年中临床分离的表皮葡萄球菌耐药性分析

目的了解2000～2004年我院临床分离的表皮葡萄球菌分布特点及其对常用抗菌药物的耐药性,以指导临床合理用药。方法应用VITEK全自动微生物分析仪以及K-B法对我院2000～2004年临床标本分离的547株表皮葡萄球菌进行鉴定和药敏试验。结果主要来自血液、呼吸道及伤口分泌物中的547株表皮葡萄球菌对万古霉素、亚胺培南具有很高的敏感性;对头孢菌素类、氨基糖甙类以及红霉素、氯霉素、克林霉素的耐药率呈逐年上升趋势;对青霉素的耐药率非常高(>80%)。结论表皮葡萄球菌对临床常用的抗菌药物耐药性严重,对其引起的感染可选用万古霉素或亚胺培南。

Analysis of Drug Resistance of Staphylococcus Epidermidis

Objective To investigate the distribution pattern and drug resistance of S. epidermidis in our hospital from 2000 to 2004. Methods VITEK-AMS system and K-B disk diffusion test were used for identification and antibiotics sensitive test in 547 S. epidermidis strains isolated from clinical patients from 2000 to 2004. Results 547 strains of S. epidermidis isolated from blood, sputum and wound secretion were highly sensitive to vancomycin and imipenem. Resistance ratio became higher and higher to cephalosporins, erythromycin, clindamycin, aminogiycosides and chloromycetin. Resistance ratio was more than 80% to penicillin. Conclusions S. epidermidis had severe resistance to normal antibiotics. Vancomycin or imipenem are effective for S. epidermidis.