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| 树突状细胞和造血干细胞移植的研究进展 | |
| 引用本文： | 汪健,王保龙. 树突状细胞和造血干细胞移植的研究进展[J]. 国际免疫学杂志, 2007, 30(5): 319-323 |
| 作者姓名： | 汪健 王保龙 |
| 作者单位： | 安徽医科大学附属省立医院输血科,合肥,230001 |
| 基金项目： | 安徽省高等学校省级科研重点项目(KJ20070A31) |
| 摘 要： | 树突状细胞(DC)是功能最强的抗原递呈细胞(APC),在移植免疫中,DC启动免疫排斥还是维持免疫耐受取决它们的起源以及成熟状态,成熟DC启动免疫排斥及移植物抗宿主病(GVHD)反应,未成熟(iDC)及淋巴样DC诱导免疫耐受。造血干细胞移植(HSCT)中,可以通过调控不同来源、不同分化状态的DC来预防和治疗移植物抗宿主病(GVHD),促进造血干细胞的植入。 |
| 关 键 词： | 树突状细胞 造血干细胞移植 移植物抗宿主病 免疫耐受 |
| 文章编号： | 1673-4394（2007）05-0319-04 |
| 修稿时间： | 2006-09-20 |
Advance in the research of dendritic cells and hematopoietic stem cell transplantation |
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| WANG Jian,WANG Bao-long. Advance in the research of dendritic cells and hematopoietic stem cell transplantation[J]. International Journal of Immunology, 2007, 30(5): 319-323 | |
| Authors: | WANG Jian WANG Bao-long |
| Affiliation: | Department of Transfusion, The Affiliated Provincial Hospital of Anhui Medical University , Hefei 230001, China |
| Abstract: | Dendritic cells (DCs) are the most potent antigen presenting cells. In transplantation immunity , whether DCs induce rejection or tolerance depends on the source and matuvation of DCs. Mature DCs are able to initiate rejection response and graft versus host disease (GVHD), while immature DCs or plasmacytoid DCs induce immunity tolerance. In hematopoietic stem cell transplantation(HSCT), different originated and differentiated DCs can be modulated to prevent and cure GVHD, and to promote engraftment of hematopoietic stem cells. |
| Keywords: | Dendritic cell Hematopoietic stem cell transplantation Graft versus host disease Immune tolerance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |