Th17细胞的研究进展

近20年来，Th1／Th2模型为理解CI4^＋T细胞在固有免疫和适应性免疫之间的相互影响提供了框架，近期的一些研究详细地描述了CI4^＋T细胞效应性应答的一个分支，以前从未被认知的细胞系——Th17细胞系有望改变我们对于免疫调节、免疫发病机理和宿主防御的理解。来源于初始T细胞前体分泌IL-17的效应T细胞如Th17细胞特异性分泌的众多因子正迅速地被发现，这些细胞因子参与了固有免疫系统信号通路的调节，为促使T细胞前体向Th1、Th2和Th17细胞的发育提供了不同的途径。

The progression of research on the Th17 lineage

In recent two decades, the Th1/Th2 paradigm has provided the framework for understanding CD4 T-cell biology and the interplay between innate and adaptive immunity. Recent studies have defined a previously unknown field of the CD4 T-cell effector response-the Thl7 lineage. This mass promises to change our understanding of immune regulation, immune pathogenesis, and host defense. The factors that specify differentiation of IL-17-producing effector T-cells from naive T-cell precursors are being rapidly discovered and are providing insights into mechanisms by which signals from cells of the innate immune system guide alternative pathways of Thl, Th2 or Thl7 development.