维生素D相关信号通路干预对骨质疏松症的影响

骨质疏松症(osteoporosis,OP)是一种临床上常见的全身代谢性骨骼疾病,其患病率也随着我国人口老龄化的不断加剧而逐年递增。正常情况下,人体骨量受到成骨细胞(osteoblast,OB)、破骨细胞(osteoclast,OC)共同调控,当成骨细胞及破骨细胞共同维持的动态平衡被打破时,骨密度(bone mineral density,BMD)就会随之产生变化。因此,如何合理有效的在一个合理区间抑制成骨细胞凋亡并促进破骨细胞凋亡是治疗骨质疏松症的一个关键且有效途径。目前有大量相关研究数据指出,部分与活性维生素D(vitamin D)相关的信号通路在调节成骨细胞、破骨细胞的生物活性、增殖及凋亡中有着显著效用,因此合理介导维生素D相关的信号通路或许是未来深入、系统探究骨质疏松症发病机制及治疗的有效手段。本文旨在对维生素D相关的信号通路予骨质疏松症的影响加以阐述、总结,也为骨质疏松症治疗及新药的开发提供一定的思路。

Effect of intervention of VitD-related signal pathway on osteoporosis

Osteoporosis (OP) is a common metabolic bone disease in clinic, and its prevalence rate is increasing year by year with the increasing aging population in China. Under normal circumstances, human bone mass is regulated by osteoblasts (OB) and osteoclasts (OC). When the dynamic balance maintained by osteoblasts and osteoclasts is broken, bone mineral density (BMD) will change. Therefore, how to reasonably and effectively inhibit osteoblast apoptosis and promote osteoclast apoptosis in a reasonable range is a key and effective way to treat osteoporosis. At present, a large number of relevant research data indicate that some of the VitD-related signaling pathways have certain effects on regulating the biological activity, proliferation, and apoptosis of osteoblasts and osteoclasts. Therefore, the reasonable mediation of VitD-related signaling pathways may be an effective means to further and systematically explore the pathogenesis and treatment of osteoporosis in the future. This paper aims to elaborate and to summarize the effects of VitD-related signaling pathways on osteoporosis, and provides some ideas for the treatment of osteoporosis and the development of new drugs.