幽门螺杆菌相关性胃炎患者血清胃蛋白酶原检测的临床价值 |
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引用本文: | 韩坤,张玲霞,张沥,庄坤,宋瑛,楚有良,张宁霞,方亚利. 幽门螺杆菌相关性胃炎患者血清胃蛋白酶原检测的临床价值[J]. 现代消化及介入诊疗, 2010, 15(6): 344-345,352 |
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作者姓名: | 韩坤 张玲霞 张沥 庄坤 宋瑛 楚有良 张宁霞 方亚利 |
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作者单位: | 西安市中心医院消化科,710003 |
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基金项目: | 陕西省科技厅科研基金[2007k09-03-(4)] |
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摘 要: | 背景幽门螺杆菌(Helicobacter pylori,Hp)可引起胃黏膜细胞的慢性炎症,并诱导胃黏膜细胞分泌胃蛋白酶原,导致血液中胃蛋白酶原含量的变化。目的探讨Hp相关性胃炎患者血清胃蛋白酶原含量变化的临床价值。方法对经胃镜和病理证实为浅表性胃炎和萎缩性胃炎的患者按照Hp阳性及阴性进行分组,采用ELISA法对其血清PGⅠ、PGⅡ含量进行检测,血清Hp-IgG抗体采用定性分析法。结果无论浅表性胃炎或萎缩性胃炎,Hp阳性组同阴性组之间比较,差异均有显著意义(P0.05);在萎缩性胃炎组中,血清PGⅠ含量较浅表性胃炎组者中明显降低,两者相比差异有显著意义(P0.05)。结论Hp感染慢性胃炎患者血清中PGⅠ、PGⅡ含量明显增加,PGⅠ含量的变化可以反映胃黏膜病变的程度。
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关 键 词: | 慢性胃炎 幽门螺杆菌 PGⅠ、PGⅡ |
Clinical value of detecting serum pepsinogen in patients with Helicobacter pylori-associated gastritis |
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Affiliation: | HAN Kun, ZHANG Ling-xia, ZHANG Li, et al. Department of gastroenterology, Xi′an Central Hospital, Xi′an 710003. |
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Abstract: | Objective Helicobacter pylori (Hp) can cause chronic inflammation and a variety of metaplasia in gastric mucosal epithelial cells, and increase pepsinogen secretion, resulting in changes of blood pepsinogen content. In this study, serum pepsinogen levels were determined in Hp-associated gastritis patients in order to understand its clinical value. Methods Superficial gastritis and atrophic gastritis patients confirmed by endoscopy and pathology were divided into Hp-positive and Hp-negative groups. Concentra... |
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Keywords: | Chronic gastritis Helicobacter pylori PGI、PGII |
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