自噬在心肌缺血/再灌注损伤中的作用及药物干预研究进展

自噬现象为真核细胞所特有,是细胞内的物质成分利用溶酶体被降解过程的统称,在正常生理情况下它能清除无用的、多余的、受损的或癌变的细胞器,维持机体内环境稳态.此外,其在疾病防治、延缓衰老等方面有不可忽视的作用.在心肌缺血/再灌注（I/R）过程中,多种因素诱导细胞的自噬活动对心肌细胞的存活具有重要意义,药物对心肌I/R过程中自噬的调控作用目前较少报道.

Progress of Autophagy in Myocardial Ischemia/Reperfusion Injury and Drug Intervention

Autophagy phenomenon is peculiar to eukaryotic cells, which refers to the process of intracel- lular substances degraded by lysosemal. In the normal physiological circumstances autophagy can clear useless,superfluous,damaged or cancerous cell organelles to maintain homeostasis of the body. In addition, autophagy cannot be ignored in the disease prevention and control, and anti-aging. In myocardial ischemia- reperfusion（I/R） process, a variety of factors induced cells autophagic activity, which plays an important role in the survival of cardiomyocytes, the autophagy regulation of drugs on myocardial I/R has not been fully reoorted so far.