辛伐他汀对冠心病合并高血压患者尿蛋白的影响

目的探讨辛伐他汀用于冠心病合并高血压患者尿蛋白改善的临床效果。方法选取同心县人民医院2009年10月至2012年10月收住院的冠心病合并高血压患者120例,采用随机数字表法将患者分为安慰剂组和辛伐他汀组,每组各60例;其中安慰剂组给予安慰剂治疗,每次40 mg,每日1次;辛伐他汀组给予辛伐他汀治疗,每次40 mg,每日1次;比较两组患者治疗前后血肌酐、尿微量白蛋白、血清超敏C反应蛋白、三酰甘油、总胆固醇、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇等实验室指标。结果治疗后两组患者各指标水平较治疗前均有显著改善（P〈0.05）,安慰剂组与辛伐他汀组治疗后比较,肌酐[（66.0±9.8）μmol/L vs（59.8±7.2）μmol/L]、尿微量白蛋白[（234.7±40.4）mg/L vs（145.1±26.7）mg/L]、血清超敏C反应蛋白[（2.20±0.41）mg/L vs（1.72±0.27）mg/L]、三酰甘油[（2.80±0.94）mmol/L vs（1.35±0.45）mmol/L]、总胆固醇[（5.39±1.02）mmol/L vs（3.22±0.68）mmol/L]、高密度脂蛋白胆固醇[（2.07±0.43）mmol/L vs（2.60±0.69）mmol/L]、低密度脂蛋白胆固醇[（3.21±1.09）mmol/L vs（2.13±0.64）mmol/L]指标的改善情况,辛伐他汀组显著优于安慰剂组（P〈0.05）。结论辛伐他汀用于冠心病合并高血压治疗可显著改善尿蛋白水平,对于延缓肾病进展具有重要意义。

The Influence of Simvastatin of Urinary Protein of Patients with Coronary Heart Disease and Hypertension

Objective To investigate the clinical effects of simvastatin for urinary protein improvement of patients with coronary heart disease and hypertension. Methods During Oct. 2009 and Oct. 2012,120 patients with coronary heart disease and hypertension from People＇s Hospital of Tongxin County and randomly divided into two groups including control group treated with placebo treatment and observation group treated with simvastatin treatment. Placebo,40 mg per time,once daily; simvastatin simvastatin treatment,40 mg per time,once daily; and the level of Cr,UMA,hsCRP,TG,TC,HDL-C and LDL-C of both groups before and after treatment were compared. Results The level of Cr[（ 66. 0 ± 9. 8） μmol/mL,（ 59. 8 ± 7. 2） μmol/mL],UMA [（ 234. 7 ± 40. 4） mg/L,（ 145. 1 ± 26. 7） mg/L],hsCRP [（ 2. 20 ± 0. 41） mg/L,（ 1. 72 ± 0. 27） mg/L],TG[（ 2. 80 ± 0. 94） mmol/L,（ 1. 35 ± 0. 45） mmol/L],TC[（ 5. 39 ± 1. 02） mmol/L,（ 3. 22 ±0.68） mmol/L],HDL-C[（ 2.07 ± 0. 43） mmol/L,（ 2. 60 ± 0. 69） mmol/L]and LDL-C[（ 3. 21 ± 1. 09） mmol/L,（ 2. 13 ± 0. 64） mmol/L]of both groups after treatment were significantly better than before treatment,and of the observation group were significantly better than control group（ P 0. 05）. Conclusion The simvastatin treatment on patients with coronary heart disease and hypertension can efficiently improve urinary protein levels,which is of great significance for delaying the progression of renal disease.