| 缝隙连接蛋白Cx43磷酸化的研究进展 |
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| 引用本文： | 严剑,洪涛. 缝隙连接蛋白Cx43磷酸化的研究进展[J]. 医学综述, 2013, 0(19): 3463-3466 |
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| 作者姓名： | 严剑 洪涛 |
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| 作者单位： | 南昌大学第一附属医院神经外科,南昌330006 |
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| 基金项目： | 国家自然科学基金（81060099） |
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| 摘 要： | 相邻细胞间最主要最快速的通讯方式是缝隙连接通道（GJ）,而缝隙连接蛋白（Cx）形成的连接子是其主要组成部分.Cx大多属于磷蛋白,其磷酸化状态不同程度地影响其自身的合成装配以及GJ的功能.Cx43是哺乳动物身上分布最广泛的Cx,尤其是在心血管系统和神经系统,它的磷酸化状态受到多重激酶途径调节,发生磷酸化的位点也不尽相同,且Cx43的磷酸化参与了多种疾病的发生、发展.
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| 关 键 词： | 缝隙连接通道 缝隙连接蛋白43 磷酸化 |
Research Progress of Cx43 Phosphorylations |
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| YAN flan,HONG Tao. Research Progress of Cx43 Phosphorylations[J]. Medical Recapitulate, 2013, 0(19): 3463-3466 |
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| Authors: | YAN flan HONG Tao |
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| Affiliation: | . ( Department of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China) |
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| Abstract: | Gap junction（G J）is the most main and rapid communication way between adjacent cells, which is composed by connexin （Cx）. Connexins mostly belong to the phosphoprotein. The phosphorylation status influences its own synthesis assembly and the function of the GJ. Cx43 is the most widely distributed connexin in mammals, especially in the cardiovascular system and nervous system. Various kinases involved in the regulation of Cx43 phosphorylation, and phosphorylation site is different, and the Cx43 phosphorylation is involved in a variety of disease development. |
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| Keywords: | Gap junction Connexin43 Phosphorylation |
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