| 老年废用性骨质疏松症的发病机制探讨 |
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| 引用本文： | 昊晨[综述],谢吟灵,史晓[审校].老年废用性骨质疏松症的发病机制探讨[J].医学综述,2013(22):4148-4150. |
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| 作者姓名： | 昊晨[综述] 谢吟灵 史晓[审校] |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院老年科,上海200437 |
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| 摘 要： | 老年人骨质疏松症与增龄性骨组织退化及废用性骨量减少有关。老年人骨折后、偏瘫、肢体或脊柱神经损伤或危重手术后会造成患者长期卧床，患肢肌力负荷减弱，骨骼肌萎缩，骨量严重流失，骨质疏松加重。该文尝试从机械外力作用、神经因子及递质减少、内分泌及细胞因子改变等方面探讨废用性骨质疏松症的发病机制。
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| 关 键 词： | 老年废用性骨质疏松 机械外力 神经因子 骨代谢 |
Exploration of Pathogenesis of Elder Disuse Osteoporosis |
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| Institution: | WU Chen,XIE Yin-ling,SHl Xiao. ( Geriatrics Department,Yneyang Hospital of Integrated Traditional Chinese amt Western Medicine,Shanghai University of Traditional Chinese Medicine ,Shanghai 200437, China) |
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| Abstract: | The pathogenesis of elder osteoporosis is related to aging bone tissue degradation and disuse osteopenia. After senile fracture, hemiplegia, nerve injury or operation, long-term bed rest may lead limb muscle strength decrease and serious loss of bone mass, and aggravated osteoporosis. Here attempts to explore the pathogenesis of elder disuse osteoporosis from the perspectives of function of the muscle mechanic, reduc- tion of the neurotrophic factor and neurotransmitter,and changes of endocrine and cytokine. |
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| Keywords: | Elder disuse osteoporosis Mechanical force Neurotrophic factor Bone metabolism |
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