Sequential synovial fluid sampling suggests plasma and synovial fluid IL-6 vary independently in rheumatoid arthritis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Sequential synovial fluid sampling suggests plasma and synovial fluid IL-6 vary independently in rheumatoid arthritis

Authors:	Perry M G Richards L Harbuz M S Jessop D S Kirwan J R

Affiliation:	Academic Rheumatology, University of Bristol, Bristol Royal Infirmary and ¹ Henry Wellcome Laboratories for Integrated Neuroscience and Endocrinology, University of Bristol, Bristol, UK

Abstract:	SIR, Inflammatory cytokines, including interleukin-6 (IL-6),are raised in rheumatoid arthritis (RA). Single paired daytimesamples show that the IL-6 and TNF- ${alpha}$ concentrations in synovialfluid exceed blood concentrations during the day [13],and these and other data suggest that joints are the source.Recent data have shown that plasma IL-6 in RA follows a circadianpattern with a peak at 6 a.m. [4]. If IL-6 is generated insidejoints and diffuses into plasma, it might be expected that thesynovial fluid IL-6 concentration

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