| 1000例不典型增生胃粘膜肿瘤相关抗原(MG_7-Ag)表达状况分析 |
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| 引用本文： | 乔泰东,张学庸,胡家露,樊代明,陈宝军,陈希陶,周绍娟,牟震先.1000例不典型增生胃粘膜肿瘤相关抗原(MG_7-Ag)表达状况分析[J].解放军医学杂志,1993(2). |
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| 作者姓名： | 乔泰东 张学庸 胡家露 樊代明 陈宝军 陈希陶 周绍娟 牟震先 |
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| 作者单位： | 第四军医大学西京医院消化病研究室
710032(乔泰东，张学庸，胡家露，樊代明，陈宝军，陈希陶，周绍娟)，第四军医大学西京医院消化病研究室 710032(牟震先) |
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| 基金项目： | 总后“八一五”攻关课题 |
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| 摘 要： | 本文采用内镜活检、病理证实并用同一标准进行分级的不典型增生胃粘膜1000例,用ABC免疫组化法进行抗胃癌单抗MG_7染色分析,以观察其肿瘤相关抗原表达的状况,为临床随访及治疗方案提供依据。结果表明,1000例不同等级的不典型增生中阳性率为42.7％。其着色特点为随着不典型增生程度加重,阳性强度也加强;着色部位以腺腔面为著。不典型增生伴有肠上皮化生者较单纯不典型增生者着色阳性强度更高,范围更广。而正常区域内均为阴性。认为MG_7染色可作为高危人群筛选的一个有用指标。
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| 关 键 词： | 单克隆抗体 不典型增生 胃肿瘤 免疫组化 |
EXPRESSION OF THE TUMOR-ASSOCIATED ANTIGEN (MG_7-Ag) IN 1 000 CASES OF ATYICAL DYSPLASIA OF THE GASTRIC MUCOSA |
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| Qiao Taidong,Zhang Xueyong,Hu Jialu,Fan Daiming,Chen Baojun,Chen Xitao,Zhou Shaojuan,Mu Zhenxian. Laboratory of Gastroenteroloyg,Xijing Hospital,The Fourth Military Medical University,Xi-an.EXPRESSION OF THE TUMOR-ASSOCIATED ANTIGEN (MG_7-Ag) IN 1 000 CASES OF ATYICAL DYSPLASIA OF THE GASTRIC MUCOSA[J].Medical Journal of Chinese People's Liberation Army,1993(2). |
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| Authors: | Qiao Taidong Zhang Xueyong Hu Jialu Fan Daiming Chen Baojun Chen Xitao Zhou Shaojuan Mu Zhenxian Laboratory of Gastroenteroloyg Xijing Hospital The Fourth Military Medical University Xi-an |
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| Institution: | Qiao Taidong,Zhang Xueyong,Hu Jialu,Fan Daiming,Chen Baojun,Chen Xitao,Zhou Shaojuan,Mu Zhenxian. Laboratory of Gastroenteroloyg,Xijing Hospital,The Fourth Military Medical University,Xi-an 710032 |
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| Abstract: | The present study consiste of 1000 formalin-fixed and paraffinembedded specimens of gastric mucosa with dysplasia, obtained during gastroscopy in the previous 10 years (1981.1-1990.2) These were confirmed pathologically and investigated with MG7, an antigastric cancer Me Ab, by the ABC method. Patient's ages ranged from 26 to 70, averaging 43 years. A positive rate of 42.7% was found among those with atypical dysplasia, whereas that of gastric cancer was 97%. Staining occurred mainly on the luminal surface of the gastric mucosa and the intensity of staining and also the number of positive cells increased with the higher degree of dysplasia, especially when accompanied by intestinal metaplasia. The above results suggested that MG7-staining might be a useful index in identifying high-risk population for close follow-up. |
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| Keywords: | Monoclonal antibody Atypical dysplasia Gastric cancer Immunohistochemistry |
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