PCNA、p53蛋白在喉癌组织的表达及临床意义

目的：探讨增殖细胞核抗原（PCNA）、抑癌基因的突变蛋白（p53）在喉癌中的表达及临床意义。方法：采用免疫组化S－P法，对58例喉癌和10例喉正常组织检测，用有关统计学方法结合临床及随访资料进行分析。结果：58例例喉癌中，PCNA、p53蛋白阳性率分别为72．41％（41／58）和51．72％（30／58）。正常组织染色阴性。喉癌组织分化、临床分期、有无淋巴结转移和复发与PCNA、p53蛋白阳性表达率有关。结论：PCNA、p53蛋白的过度表达与喉癌预后有关。

The clinical implication of experession for both PCNA and p53 protein in larynx cancer patients

Objectives To analyze the clinical implication and expression of PCNA and p53 protein in larynx cancer patients.Methods We made the analysis by using immunohistochemistry S-P method,statistic method,and clinical information.Results The positive rates for PCNA and p53 protein in 58 cases are 72.4% and 51.72%.While the normal shows negative.We found that the pathological histodifferentiation,tumor calssification,lymphatic metastasis,and recurrence are related to the positive expression for both PCNA and p53 protien.Conclusion The overexperssion of PCNA and p53 protein may relate to the prognosis of larynx cancer.