纳洛酮对脑出血大鼠抓握能力的改善及血清S100B水平的影响

目的：探讨纳洛酮对脑出血大鼠抓握能力的改善及血清S100B水平的影响，为其临床应用提供理论依据。方法：40只SD大鼠随机分成假手术组，手术组，纳洛酮组，脑复康组，参照Rosenberg法制作大鼠脑出血模型，造模第二天测定大鼠抓握能力，用ELISA法检测造模后24小时及48小时血清S100B水平。结果：（1）纳洛酮组大鼠抓握能力明显好于手术组，两者比较有显著差异（P<0.05）。（2）纳洛酮组大鼠血清S100B水平明显低于手术组, 两者比较有显著差异（P<0.05）。结论：纳洛酮能明显改善脑出血大鼠抓握能力，降低血清S100B水平，具有神经保护作用。

Effects of naloxne on hold-abilities and serum S100B protein of the intracerebral hemorrhage rats

Objective To observe the effects of naloxne on hold-abilities and serum S100B protein of the intracerebral hemorrhage(ICH) rats. Methods Forty SD rats were randomly divided into sham-operation group(n=10), operation group(n=10), naloxne group(n=10) and piracetam group(n=10). The ICH model of rats was made according to Rosenberg method. Serum S100B protien was detected by ELISA method at 24 and 48 h and the hold-abilities of ICH rats were observed at the second day. Results Naloxne could significantly improve the hold-abilities of ICH rats as comparing with the operation group(P < 0.05). The levels of serum S100B protein was significantly lower in naloxne group than that in operation group(P < 0.05). Conclusion Naloxne can significantly improve the hold-abilities of ICH rats and decrease the levels of serum S100B protein, and then protect the intracerebral nerves from the injury induced by cerebral hemorrhage.