Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys |
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| Authors: | Michael R. Weed Kimberly E. Vanover William L. Woolverton |
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| Affiliation: | (1) Department of Pharmacological and Physiological Sciences, University of Chicago, 60637 Chicago, IL, USA;(2) Committee on Biopsychology, University of Chicago, 60637 Chicago, IL, USA;(3) Department of Psychiatry, Drug Abuse Research Center, Pritzker School of Medicine, University of Chicago, 60637 Chicago, IL, USA;(4) Present address: Lederle Laboratories, CNS Research Department, Medical Research Division, American Cyanamid Company, 10965 Pearl River, NY, USA |
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| Abstract: | ![]()
Rhesus monkeys with IV catheters were allowed to self-administer cocaine for 1 h/day. When responding was stable, saline or the D1 dopamine agonist SKF 81297 (SKF; 0.001–0.3 mg/kg/inj) was substituted for cocaine. At least two doses of SKF maintained responding above saline levels in all monkeys. The D1 antagonist SCH 39166 (0.001–0.03 mg/kg, IM) was then administered 30 min before sessions of self-administration of the lowest dose of SKF that maintained behavior (0.01 mg/kg/inj). SKF-maintained responding decreased in a dose-related manner, suggesting antagonism of the reinforcing effect. These results suggest that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission. |
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| Keywords: | Self-administration Dopamine D1 receptors |
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