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| EB病毒EA/IgA抗体定量检测在鼻咽癌血清学诊断中的意义 | |
| 引用本文： | 钟亮星,段辉,邓粤敏. EB病毒EA/IgA抗体定量检测在鼻咽癌血清学诊断中的意义[J]. 现代检验医学杂志, 2006, 21(2): 58-59 |
| 作者姓名： | 钟亮星 段辉 邓粤敏 |
| 作者单位： | 广州市肿瘤医院,广州医学院临床肿瘤研究中心,广东,广州,510095 |
| 摘 要： | 目的采用酶联免疫吸附法(EL ISA)定量测定EB病毒抗早期抗原的IgA水平(EA/IgA)在鼻咽癌血清学诊断中的临床价值。方法用EL ISA法定量检测血清EB病毒EA/IgA水平,其中鼻咽癌134例,头颈部其它恶性肿瘤56例,鼻咽部非癌疾病47例,健康对照组50例。结果被检血清中鼻咽癌组EA/IgA检测结果阳性率50%,平均值x-=53.27u/m l,特异性100%,健康对照组检测结果平均值x-=3.50u/m l。结论EB病毒EA/IgA抗体定量检测对鼻咽癌具有高度的特异性(100%),是一项较好的临床诊断辅助指标。 |
| 关 键 词： | 鼻咽肿瘤/诊断 酶联免疫吸附测定 EpsteinBarr病毒 抗体 早期抗原 |
| 文章编号： | 1671-7414（2006）02-058-02 |
| 收稿时间： | 2005-06-01 |
| 修稿时间： | 2005-06-01 |
The Significance of the Quantitative Detection for EBV EA/IgA Antibody in Nasopharyngeal Carcinoma (NPC) Serologic Diagnosis |
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| ZHONG Liang-xing,DUAN Hui,DENG Yue-min. The Significance of the Quantitative Detection for EBV EA/IgA Antibody in Nasopharyngeal Carcinoma (NPC) Serologic Diagnosis[J]. Journal of Modern Laboratory Medicine, 2006, 21(2): 58-59 | |
| Authors: | ZHONG Liang-xing DUAN Hui DENG Yue-min |
| Affiliation: | The Clinical Center for Cancer Research of Guangzhou Medical College, Guangzhou Tumor Hospital, Guangdong Guangzhou 510095, China |
| Abstract: | Objective To study the significance of the quantitative detection for IgA antibody to EB virus early antigen(EA/IgA) by enzyme linked immunosorbent sandwich assay(ELISA) in NPC serologic diagnosis.Methods Serum Epstein-Barr virus(EBV) EA/IgA were detected by enzyme linked immunosorbent sandwich assay(ELISA) in 134 nasopharyngeal carcinoma(NPC) patients,15 patients with other malignancies of head and neck,47 patients with nonmalignant diseases of nasopharynx and 50 normals.Results The positive rate of serum in NPC EBV-EA/IgA were 50%,the mean value was 53.27 u/ml,specificity was 100%.In the healthy group,the mean value was 3.50 u/ml.Conclusion The quatitative check of EA/IgA antibody to EB virus has a high specificity to NPC and is a good diagnosis indicator in clinics. |
| Keywords: | nasopharyngeal carcinoma ELISA Epstein Barr Virus antibody early antigen |
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