| 盐酸格拉司琼中间体的合成 |
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| 引用本文： | 龚元,李咏梅. 盐酸格拉司琼中间体的合成[J]. 黔南民族医专学报, 2004, 17(3): 134-135 |
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| 作者姓名： | 龚元 李咏梅 |
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| 作者单位： | 黔南民族医学高等专科学校药学系,贵州,都匀,558000;黔南民族医学高等专科学校药学系,贵州,都匀,558000 |
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| 摘 要： | 目的：实验探讨盐酸格拉司琼之中间体1-甲基-吲哒唑-3-羧酸经1H-吲哒唑-3-羧酸甲基化制备的方法及工艺。方法：通过可能产生影响的各种因素进行综合考虑分批实验。结果：产品产率70％,转换率90％,熔点215～216℃,纯度95％以上。结论：该实验产品完全满足后续生产制备需要。
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| 关 键 词： | 格拉司琼 1H-吲哒唑-3-羧酸 1-甲基-吲哒唑-3-羧酸 合成 |
| 文章编号： | 1008-4983(2004)03-0134-02 |
| 修稿时间： | 2004-05-06 |
How to Compose the Intermediate Compound of Granisrtron Hydrochloride |
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| Gong Yuan,Li Yongmei. How to Compose the Intermediate Compound of Granisrtron Hydrochloride[J]. Journal of Qiannan Medical College for Nationalities, 2004, 17(3): 134-135 |
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| Authors: | Gong Yuan Li Yongmei |
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| Affiliation: | Gong Yuan,Li Yongmei Qiannan Medical College for Nationalities Minorities,Duyun Guizhou 558000 |
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| Abstract: | Objective: The experiment discusses the method and Ihe craft of preparation that 1 -methyl - indazol - 3 - carboxylic acid the intermediate compound of granisrtron hydrochloride through the 1H- indazol - 3 - carboxylic acid methylation. Methods: Proceed multiple consideration through all possible in-fluential causes. Results: The product accords with the require report of the literature. Conclusions: Fullfillthe demands of subsequent preparation. |
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| Keywords: | granisetron 1H-indazol-3-carboxylicacid 1-methly-indazol -3 -carboxylic acid compose |
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