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Endoscopic management of pancreatic fistula after distal pancreatectomy and enucleation
Authors:Goasguen Nicolas  Bourrier Anne  Ponsot Philippe  Bastien Laurence  Lesurtel Mickael  Prat Frederic  Dousset Bertrand  Sauvanet Alain
Affiliation:a Department of Hepatobiliary and Pancreatic Surgery, AP-HP, Beaujon Hospital, University Paris VII, 100 Boulevard du Général Leclerc, 92100, Clichy, France
b Department of Gastroenterology, AP-HP, Cochin Hospital, Paris, France
c Department of Gastroenterology, AP-HP, Beaujon Hospital, Clichy, France
d Department of Digestive Surgery, AP-HP, Cochin Hospital, Paris, France
Abstract:

Background

Preoperative endoscopic pancreatic sphincterotomy (EPS) has been proposed to prevent postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP) or enucleation (EN). The use of EPS as a curative treatment for POPF has been scarcely reported. We reported 10 consecutive patients who were successfully treated by EPS for a prolonged POPF.

Study design

Ten patients underwent EPS for prolonged POPF (median duration = 40 days, range 20-114; median daily output = 80 mL, range 50-250) after 6 DPs, 2 ENs, and 2 medial pancreatectomies.

Results

EPS was performed in all patients, with stent insertion in 4. No patient developed a specific complication because of EPS. POPF healed within a median delay of 4 days (range 1-12). One patient underwent a repeated endoscopy to treat stent malposition. The median delay of discharge after EPS was 13 days (range 8-15). With a 20-month median follow up, 1 patient developed early transient POPF recurrence because of spontaneous stent migration.

Conclusions

EPS is indicated for prolonged POPF after DP or EN because it is highly feasible, shortens healing, and is well tolerated.
Keywords:Distal pancreatectomy   Endoscopic pancreatic sphincterotomy   Pancreatic enucleation   Pancreatic fistula   Pancreatic stent
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