射频多极针消融仪治疗肺癌的近期临床研究

目的 :研究射频多极针对肺癌的治疗作用。方法 :采用WE75 6 8射频多极针肿瘤消融仪 ,对 4 2例肺癌的病人 ,经胸腔镜或开放手术直视下或CT定位下行肺癌肿块消融术 ,2 5例消融术后即行病灶肺叶切除术 ,病灶送病理 ,观察消融对肺癌细胞作用后的病理变化和该术式的不良反应。结果 :消融后大部分肿瘤可见较多片状 ,小灶性坏死 ,在坏死中间及边缘可见部分癌细胞核固缩 ,核分裂 ,部分空泡变性 ,嗜酸性变。部分癌细胞巢的中央见细胞松懈、脱落 ,或见纤维素样坏死或癌细胞广泛变形。从坏死边缘残留的癌细胞巢到正常肺组织距离为 0 .0 1～ 0 .2cm左右 ,坏死灶中间及边缘有大量中性白细胞渗出 ,低分化与中分化癌细胞对温度耐受无明显差别。结论 :带有射频多极针的WE75 6 8肿瘤消融仪 ,对肺癌治疗具有较好的近期疗效 ,能够使肿瘤病灶大部分坏死 ,明显地减缓肿瘤的发展 ,减少疼痛 ,有效地改善患者的生活质量 ,但目前仍未证实其具有根治作用

RF MULTI-HOOK PROBE FOR TREATMENT OF LUNG CANCER: PRIMARY CLINICAL RESEARCH REPORT

Objective:To determine the ablation effect of RF multi-hook probe for treatment of lung cancer.Methods: Forty-two cases of lung cancer were treated with RF multi-hook probe ablation under thoroscopical direct vision or open surgery and CT guide.Among them 25 cases were performed loboresectomy after ablation,and the ablation lesion were carefully examined by pathology.Results:The majority of tumor cell presented significant pathological change after RF ablation and there were not differential influence on tumor cell which either were low grade or high grade for tolerance of temperature.Conclusions:RF multi-hook probe interstitial ablat ion of WE7568 machine is an effective and safe new treatment for lung cancer.