青岛市某高校女职工宫颈脱落细胞感染人乳头瘤病毒型别调查

目的 调查中国石油大学(华东)青岛校区女职工群体宫颈脱落上皮细胞中人乳头瘤病毒(HPV)感染状况及病毒不同基因亚型的分布状况,为本校制定女职工两癌筛查及防治策略提供科学依据,也为青岛地区高校女职工群体HPV感染状况研究提供数据支持。方法 收集2016年在校医院体检的女职工自愿进行宫颈脱落上皮细胞HPV检测的结果,然后进行统计分析。结果 1 520名进行HPV检测的女职工总体感染率为12.37%,其中高危型HPV(HR-HPV)与低危型HPV(LR-HPV)构成比分别为68.09%、31.91%;该群体感染HR-HPV主要亚型为52亚型、58亚型、39亚型,感染LR-HPV主要亚型为42亚型、53亚型、6亚型;单一HPV病毒亚型感染占75.53%,多重感染占24.47%,多重感染的多发基因亚型与人群感染HPV主要基因亚型不完全相同;不同年龄段的职工HPV感染率不同,多重感染率也不同,按年龄段均呈不对称的“U”型分布。结论 本调查人群感染率略高于其他地区高校群体,人群HPV感染主要基因亚型也不同,校医院对不同年龄段的职工应制定有针对性的指导、检测、治疗和随访策略,降低本人群的HPV感染率和宫颈癌的发生率。

Investigation on human papillomavirus types of cervical exfoliated cells in female university staff in Qingdao City

Objective To investigate the infectious conditions of human papillomavirus (HPV) and the distribution of its different gene subtypes in cervical exfoliated epithelial cells of female workers in the Qingdao campus of China University of Petroleum (Hua Dong), so as to provide the evidence for the development of “two-cancer” screening and prevention strategies, and the data support for the study of HPV infection in female college workers in Qingdao area.Methods The HPV detection results of cervical exfoliated epithelial cells of school female workers who took part in the physical examinations were collected and statistically analyzed in 2016. Results Among the 1 520 female workers, the overall HPV infection rate was 12.37%, including high-risk HPV (HR-HPV, 68.09%) and low risk HPV (LR-HPV, 31.91%). The main subtypes of HR-HPV infection group included 52-subtype, 58-subtype, and 39-subtype; the main subtypes of LR-HPV infection group included 42-subtype, 53-sub type, and 6-subtype. The single subtype infection accounted for 75.53% and the multiple infections accounted for 24.47%. The multiple subtypes and multiple infection population HPV genotypes were not exactly the same. The workers of different ages had different HPV infection rates and different multiple infection rates, and both presented asymmetric "U" type distributions.Conclusion The HPV infection rate of the surveyed population is slightly higher than that of other groups in the surveyed area, and the main subtypes of HPV are also different. Therefore, the targeted strategies of guidance, detection, treatment and follow-up need to be formulated according to the characteristics of the different age groups, so as to reduce the HPV infection rate and cervical cancer incidence.