ICU获得性肌无力的研究进展

很多急危重症或经历复杂手术的患者往往需要入住重症监护病房（ICU）治疗，以期平稳度过危险期。其中，部分患者因多种原因而出现不同程度的肢体无力、呼吸肌力量减弱、深反射减弱等症状，对此现象国外学者提出了ICU获得性肌无力（IUCAW）的概念。据报道ICUAW诊断困难、恢复缓慢是导致患者撤机困难、住院时间延长的主要原因之一，对急危重症患者的预后产生了巨大的影响，从社会经济学角度而言也造成了医疗资源的过度消耗。随着电生理学及各种诊断方法的进展，在ICUAW的发病机制及治疗措施等方面均取得了长足的进步。本文将围绕ICUAW的定义及分类、基本特征、病理生理机制、诊断及防治进行概述。

Recent advance in intensive care unit-acquired muscle weakness

Many critically ill patients or those who experienced complicated operations often need to be treated in the intensive care unit (ICU) to get through the dangerous period. Among them, some patients have diferent degrees of limb weakness, weakness of respiratory muscle strength, diminished deep tendon reflex and other symptoms for a variety of reasons, and the concept of ICU-acquired weakness (ICUAW) has been proposed for this phenomenon by some researchers. It is reported that the difficulty in diagnosis of ICUAW and its slowly recovery are main reasons leading to the difficulty of weaning and prolonged hospitalization, which have a great impact on the positive prognosis of critically ill patients. What’s more, it also causes the excessive consumption of medical resources from the perspective of social economics. With the progress of electrophysiology and various diagnostic methods, considerable progress has been made in the pathogenesis and treatment of ICUAW. This article will make an overview focusing on the definition and classification, basic features, pathophysiological mechanisms, diagnosis and prevention of ICUAW.