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| 四例结直肠少见类型的混合性腺神经内分泌癌（MANEC）病例报道 | |
| 引用本文： | 关剑,邹霜梅. 四例结直肠少见类型的混合性腺神经内分泌癌（MANEC）病例报道[J]. 中华结直肠疾病电子杂志, 2018, 7(4): 393-397. DOI: 10.3877/cma.j.issn.2095-3224.2018.04.018 |
| 作者姓名： | 关剑 邹霜梅 |
| 作者单位： | 1. 100021 北京，国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院病理科 |
| 基金项目： | 国家重点研发计划(No.2016YFC0905300) |
| 摘 要： | 混合性腺神经内分泌癌（MANEC）是一类罕见肿瘤，由至少各占30%的腺癌和神经内分泌肿瘤组成。本文报道了4例少见类型的结直肠MANEC，其中一例由低级别神经内分泌肿瘤（G1）和高分化管状腺癌组成，另外三例由高级别神经内分泌肿瘤（G3）和中——低分化腺癌组成。从以上病例总结中发现，MANEC的神经内分泌肿瘤成分具有更强的侵袭力和淋巴结转移率，所以目前MANEC的分级应该根据不同肿瘤成分进行更加细化的分类。 |
| 关 键 词： | 结直肠肿瘤 混合性腺神经内分泌癌 神经内分泌肿瘤 |
| 收稿时间： | 2017-09-17 |
Colorectal mixed adenoneuroendocrine carcinoma (MANEC): report of four cases |
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| Jian Guan,Shuangmei Zou. Colorectal mixed adenoneuroendocrine carcinoma (MANEC): report of four cases[J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2018, 7(4): 393-397. DOI: 10.3877/cma.j.issn.2095-3224.2018.04.018 | |
| Authors: | Jian Guan Shuangmei Zou |
| Affiliation: | 1. Pathology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China |
| Abstract: | Mixed adenoneuroendocrine carcinoma (MANEC) is an extremely rare tumor, composes of two components as adenocarcinoma and neuroendocrine tumor with each portion is no less than 30%. We present four cases of MANEC in colorectum, which showed different combination of two components. One was low grade neuroendocrine tumor (G1) with well-differentiated tubular adenocarcinoma. Three were high grade neuroendocrine carcinoma (G3) with moderate differentiated adenocarcinoma. The neuroendocrine part in MANEC showed deeper infiltration and more lymph node metastasis. And with different combination of two components in tumors, MANEC should be stratified in different prognostic categories according to the grade of malignancy of each component. |
| Keywords: | Colorectal neoplasms Mixed adenoneuroendocrine carcinoma Neuroendocrine tumor |
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