质子泵抑制剂在消化性溃疡临床治疗中的疗效观察

目的 分析与观察质子泵抑制剂在消化性溃疡临床治疗的疗效。方法 选择富县人民医院消化内科2015-08~2017-08期间收治的消化性溃疡患者117例,按照来院就诊时间将其平均分为A组、B组和C组,每组患者39例,给予A组患者第一代质子泵抑制剂奥美拉唑、甲硝唑、克拉霉素和硫糖铝;给予B组患者第二代质子泵抑制剂兰索拉唑、甲硝唑、克拉霉素和硫糖铝;给予C组患者第三代质子泵抑制剂雷贝拉唑、甲硝唑、克拉霉素和硫糖铝,其后比较三组患者的临床治疗效果、幽门螺杆菌根除率和不良反应发生率。结果 B组、C组患者的临床治疗效果和幽门螺杄菌根除率明显优于A组,且组间存在差异显著,P<0.05。B组患者与C组患者的不良反应发生率明显低于A组,组间经比较后存在显著性差异,P<0.05。结论 在幽门螺杆菌消化性溃疡治疗中采用兰索拉唑和雷贝拉唑,加之联合抗菌药物和抗生素,其治疗效果显著,不仅具有较高的幽门螺杆菌清除率,同时降低不良反应,值得在临床上更进一步的应用及推广。

Therapeutic effect of proton pump inhibitors on clinical treatmentof peptic ulcer

Objective To analyze and observe the efficacy of proton pump inhibitors in the clinical treatment of peptic ulcer. Methods A total of 117 patients with peptic ulcer admitted to the department of gastroenterology, Fuxian People′s Hospital from August 2015 to August 2017 were enrolled. According to the time of hospital visit, 117 patients were equally divided into group A, group B and group C, with 39 patients in each group. The first-generation proton pump inhibitors omeprazole, metronidazole, clarithromycin and sucralfate were given to group A patients; the second-generation proton pump inhibitors lansoprazole, metronidazole and carrageenan were given to group B patients. And sucralfate; the third-generation proton pump inhibitors rabeprazole, metronidazole, clarithromycin and sucralfate were given to patients in group C. The clinical effects of the three groups of patients, the eradication rate of Helicobacter pylori and the incidence of adverse reactions were compared. Results The clinical treatment effect and the eradication rate of Helicobacter pylori in group B and C were significantly better than those in group A, and there was significant difference between the two groups (P<0.05). The incidence of adverse reactions in group B and group C was significantly lower than that in group A. There was significant difference between groups (P<0.05). Conclusion The combination of lansoprazole and rabeprazole in the treatment of Helicobacter pylori peptic ulcer, combined with antibiotics and antibiotics, has a significant therapeutic effect, which not only has a high clearance rate of Helicobacter pylori, but also reduces adverse reactions. It is worth further application and promotion in the clinic.