住院患者抗菌药物临床应用横断面调查

目的了解解放军总医院第一附属医院抗菌药物应用情况及合理性。方法采用横断面调查方法,调查某日全天的全院住院患者抗菌药物的使用情况。结果在本院住院的1 598例住院患者中,抗菌药物横断面使用率为31.10%,联合用药比例为37.98%。内科系抗菌药物使用率(33.62%)高于外科系(28.89%)。联合用药率最高的是妇科,为72.73%。用药频度(DDDs)排名前10位的抗菌药物中,β-内酰胺酶类抗生素配伍复方制剂和头孢菌素类6个,氟喹诺酮类1个,青霉素类1个,硝基咪唑类1个,碳青霉烯类1个;病原学送检率为34.34%。结论该院抗菌药物横断面使用水平基本合理,但β-内酰胺酶类抗生素配伍复方制剂使用频率过高,有过度使用的可能性,病原学送检率低,需要进一步加强抗菌药物合理应用的管理。

Clinical application of antibacterial drugs for inpatients:A cross-sectional study

Objective To investigate the clinical application of antibacterial drugs for inpatients of a hospital and its rationality. Methods A cross-sectional survey was used to investigate the status of use of antimicrobial drugs in all the inpatients within one day. Results Among 1 598 inpatients,the rate of antibacterial use was 31.10%,and the combined medication rate was 37.98%.The rate of antibacterial use in the medical wards was higher than that in the surgical wards(33.62% vs 28.89%).Besides,the combined medication rate was the highest in department of gynecology(72.73%).The top ten DDDs of drugs were 6 of β-Lactam antibiotics and cephalosporins,1 of fluoroquinolones,1 of penicillins,1 of nitroimidazoles,and 1 of carbapenems.Rate of etiological examination for therapeutic medication in the hospital was 34.34%. Conclusion The cross-sectional antibacterial use in the hospital goes well,but the DDDs of β-Lactam antibiotics is higher,suggesting to be overused.The rate of etiological examination is lower,thus the management should be reinforced for the rational use.