吴茱萸萃取物对虚寒证模型大鼠T3、T4、TSH、TRH含量的影响

目的:研究吴茱萸提取物对虚寒大鼠甲状腺功能的影响。方法:大鼠随机分为空白对照组、虚寒模型组、热性趋势标记组、寒性趋势标记组、水煎液萃取物组。中药复方水煎液灌胃造成大鼠虚寒模型,之后给予吴茱萸提取物进行治疗。采用ELISA检测各组动物的T3、T4、TSH、TRH。结果:与虚寒模型相对比,吴茱萸萃取物T3、T4、TSH、TRH均有升高趋势,其中热性趋势标记组,寒性趋势标记组、水煎液组TSH、TRH均明显升高(P<0.05),差异具有显著性。结论:吴茱萸萃取物对虚寒大鼠甲状腺的功能具有不同程度的改善作用。

Influence of Extract from Evodia on the Contents of T3 T4 TSH and TRH in Deficiency Cold Syndrome Rat Models

Objective:Effects of extract from Evodia on thyroid in deficiency cold syndrome rats.Methods:Rats were randomly divided into blank control group(group 1),model group deficiency(group 2),hot trend marked group(group 3),cold trend marked group(group 4),extract decoction group(group 5).Traditional Chinese medicine decoction was given to deficiency cold model rats,then the extract from Evodia was given to rats for treatment.T3,T4,TSH and TRH were tested by ELISA in each group.Results:Compared with group 2,the contents of T3,T4,TSH and TRH in group 3 to 5 had increased tendency.The contents of TSH and TRH in group 3 to 5 were significantly increased(P<0.05)and the difference was significant.Conclusion:Extract from Evodia had certain function of promoting thyroid in deficiency cold syndrome model rats.