| 豚鼠皮肤球形马拉色菌感染模型的建立 |
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| 引用本文： | 朱敏,王侠生,章强强,王家俊,李莉. 豚鼠皮肤球形马拉色菌感染模型的建立[J]. 临床皮肤科杂志, 2006, 35(3): 154-156 |
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| 作者姓名： | 朱敏 王侠生 章强强 王家俊 李莉 |
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| 作者单位： | 复旦大学附属华山医院皮肤科,上海,200040;复旦大学附属华山医院皮肤科,上海,200040;复旦大学附属华山医院皮肤科,上海,200040;复旦大学附属华山医院皮肤科,上海,200040;复旦大学附属华山医院皮肤科,上海,200040 |
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| 摘 要： | 目的：建立皮肤球形马拉色菌感染的动物模型。方法：分别采用涂菌1次法、涂菌1次并皮下注射甲泼尼龙法、连续7d涂菌法3种方法诱导豚鼠皮肤感染球形马拉色菌。结果：连续7d涂菌法适合于此模型的建立，得到了满意的皮损及菌落数。结论：皮肤菌落计数能更直观、客观地反映药物的短期疗效，是评价皮肤球形马拉色菌感染模型较科学的指标。
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| 关 键 词： | 马拉色菌 球形 皮肤 动物模型 豚鼠 |
| 文章编号： | 1000-4963（2006）03-0154-03 |
| 收稿时间： | 2005-06-21 |
| 修稿时间： | 2005-06-212005-10-07 |
A novel model of cutaneous Malassezia globosa infection in guinea-pigs |
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| ZHU Min,WANG Xia-sheng,ZHANG Qiang-qiang,WANG Jia-jun,LI Li. A novel model of cutaneous Malassezia globosa infection in guinea-pigs[J]. Journal of Clinical Dermatology, 2006, 35(3): 154-156 |
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| Authors: | ZHU Min WANG Xia-sheng ZHANG Qiang-qiang WANG Jia-jun LI Li |
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| Affiliation: | Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China |
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| Abstract: | Objective:To develop an animal model of cutaneous Malassezia globosa infection.Methods:Experimental cutaneous Malassezia globosa infection was achieved in guinea pigs by 3 methods(one-time inoculum,one-time inoculum plus three-time subcutaneous injections of methyl-prednisolone,and daily inoculum for 7 consecutive days).Results:The daily inoculum for 7 consecutive days was suitable for the animal model that got higher lesion scores and CFU(colony forming unit)number.Conclusion:CFU number is an useful parameter for the study on the animal model of cutaneous Malassezia globosa infection. |
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| Keywords: | Malassezia globosa skin animal model guinea pigs |
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