| 木犀草素缩磺胺甲恶唑席夫碱及金属配合物的研究 |
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| 引用本文： | 沙靖全,李敬芬,闫红. 木犀草素缩磺胺甲恶唑席夫碱及金属配合物的研究[J]. 黑龙江医药科学, 2005, 28(4): 8-9 |
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| 作者姓名： | 沙靖全 李敬芬 闫红 |
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| 作者单位： | 佳木斯大学化学与药学院,黑龙江,佳木斯,154007;浙江湖州师范学院,浙江,湖州,313000 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目10541222 |
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| 摘 要： | 目的:寻找新型席夫碱和新的抑菌药物。方法:以木犀草素和磺胺甲恶唑进行缩合反应制成新的黄酮席夫碱化合物;并以此为配体合成了新的金属配合物。进行了初步的抗菌活性实验。结果:经元素分析、红外光谱、紫外光谱确证其结构组成。结论:结果表明,新化合物对多种菌株有明显的抑菌活性且优于各自的母体。
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| 关 键 词： | 木犀草素 磺胺甲恶唑 合成 配合物 生物活性 |
| 文章编号： | 1008-0104(2005)04-0008-02 |
| 修稿时间： | 2005-06-24 |
Synthesis and antibacterial activity of iuteolin flavone complex |
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| SHA Jing-quan,LI Jing-fen,YAN Hong. Synthesis and antibacterial activity of iuteolin flavone complex[J]. Heilongjiang Medicine and Pharmacy, 2005, 28(4): 8-9 |
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| Authors: | SHA Jing-quan LI Jing-fen YAN Hong |
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| Affiliation: | SHA Jing-quan1,LI Jing-fen2,YAN Hong1 |
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| Abstract: | Objective: To seek new antibacterial agents. Method: On the base of luteolin and schiff base, by condensation reaction, new antibacterial schiff base and its complexes were synthesized, and the antibacterial activity was examined. Results: These compounds were characterized by the elemental analysis, IR and UV-visible spectra. Conclusion: They have more obvious antibacterial activity compared with their primary compounds. |
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| Keywords: | luteolin sulfamethazole synthesise chelates antibacterial activity |
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