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Regulation of the Caenorhabditis elegans posterior hox gene egl‐5 by microRNA and the polycomb‐like gene sop‐2
Authors:Hongjie Zhang  Scott W. Emmons
Affiliation:Department of Genetics, Albert Einstein College of Medicine, Bronx, New York
Abstract:
In Caenorhabditis elegans, the domains of Hox gene expression are controlled by the novel global regulatory gene sop2. We identified a region located 3′ of the Hox gene egl5 that promotes ectopic expression of an egl5 reporter gene in a sop2 mutant. SOP‐2 could directly block positive regulatory factors acting in this region, or it could block their expression. We identified three possible miRNA binding sites within the egl5 3′ untranslated region (UTR). Cognate microRNAs are expressed in relevant tissues and can block egl5 expression when expressed from a transgene. Mutation of the putative binding sites in the egl5 3′UTR resulted in a modest degree of misexpression of a minimal egl5 reporter gene, suggesting that microRNAs may contribute to the tight restriction of egl5 expression to particular cell lineages. Developmental Dynamics 238:595–603, 2009. © 2009 Wiley‐Liss, Inc.
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