Akinetic mutism: pharmacologic probe of the dopaminergic mesencephalofrontal activating system |
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| Authors: | H C Echiverri W O Tatum T A Merens S B Coker |
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| Affiliation: | Department of Neurology, Loyola University Medical Center, Maywood, IL 60153. |
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| Abstract: | ![]()
Four children who exhibited akinetic mutism during the course of their neurologic diseases were treated with bromocriptine. Reversal of the akinetic mute states was evident in all patients. Pathways of the dopaminergic neurons are reviewed and a clinically useful mechanism which causes akinetic mutism is postulated. |
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