An inv(16) in Ph-negative cells of a chronic myelogenous leukemia patient after imatinib treatment |
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| Authors: | Rowe Leslie R Brothman Arthur R Nibley William E Gaffney Michael R Chen Zhong |
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| Affiliation: | Institute for Clinical and Experimental Pathology, Associated Regional and University Pathologists (ARUP) Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108-1221, USA. rowelr@aruplab.com |
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| Abstract: | ![]()
Secondary chromosomal changes are known to develop in Philadelphia chromosome-negative (Ph-) cells of chronic myelogenous leukemia (CML) patients after treatment with imatinib mesylate, an ABL kinase inhibitor. We report here a novel case of a pericentric inversion of chromosome 16 as the sole cytogenetic abnormality in Ph- cells after treatment of Ph+ CML with imatinib. |
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