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| 槐果碱及氧化槐果碱对小鼠的急性毒性 | |
| 引用本文： | 钱利武,戴五好,王丽丽,周国勤,张毅,汪海孙. 槐果碱及氧化槐果碱对小鼠的急性毒性[J]. 中国实验方剂学杂志, 2012, 18(13): 256-258 |
| 作者姓名： | 钱利武 戴五好 王丽丽 周国勤 张毅 汪海孙 |
| 作者单位： | 1. 安徽省药物研究所,合肥230022;安徽省中药研究与开发重点实验室,合肥230022 2. 安徽中医学院,合肥,230031 3. 安徽医学高等专科学校,合肥,230601 4. 安徽省药物研究所,合肥,230022 |
| 基金项目： | 长三角地区科技联合攻关项目(10140702018);安徽省高层次人才创新创业资金(2009Z064) |
| 摘 要： | 目的:探讨槐果碱及氧化槐果碱对昆明小鼠的急性毒性反应.方法:通过向昆明小鼠尾静脉注射不同浓度的槐果碱及氧化槐果碱溶液,观察并记录槐果碱及氧化槐果碱对小鼠的毒性反应.利用SPSS13.0统计学软件计算其对小鼠的半数致死量( LD50).结果:昆明小鼠对槐果碱及氧化槐果碱单次尾静脉注射LD50分别为63.94,250.37 mg·kg -1,二者95％可信区间分别为56.49～73.08 mg· kg-1,219.05～288.02 mg·kg-1.结论:槐果碱和氧化槐果碱单次尾静脉注射对昆明小鼠有一定的毒性,槐果碱的氧化产物毒性明显降低. |
| 关 键 词： | 槐果碱 氧化槐果碱 急性毒性 半数致死量 置信区间 |
| 收稿时间： | 2011-11-24 |
Toxicity Study on Sophocarpine and Oxysophocarpine in Mice |
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| QIAN Li-wu,DAI Wu-hao,WANG Li-li,ZHOU Guo-qin,ZHANG Yi and WANG Hai-sun. Toxicity Study on Sophocarpine and Oxysophocarpine in Mice[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(13): 256-258 | |
| Authors: | QIAN Li-wu DAI Wu-hao WANG Li-li ZHOU Guo-qin ZHANG Yi WANG Hai-sun |
| Affiliation: | Anhui Institute of Materia Medica, Hefei 230022, China;Key Laboratory of Research and Development of Chinese Medicine of Anhui Province, Hefei 230022, China;Anhui University of Traditional Chinese Medicine, Hefei 230031, China;Anhui Medical College, Hefei 230601, China;Anhui Institute of Materia Medica, Hefei 230022, China;Anhui Institute of Materia Medica, Hefei 230022, China;Anhui Institute of Materia Medica, Hefei 230022, China |
| Abstract: | Objective: To explore the acute toxicity of sophocarpine and oxysophoca rpine in Kunming mice. Method: The drugs were administered in mice via the tail vein injection. The toxic reactions were recorded and the medium lethal dose (LD50) was calculated by spss 13.0. Result: The LD50 of sophocarpine and oxysophocarpine was 63.94, 250.37 mg·kg-1, its 95% confidence interval was 56.49-73.08 mg·kg-1 and 219.05-288.02 mg·kg-1, respectively. Conclusion: Acute toxicity experiment showed that the sophocarpine and oxysophocarpine have some toxic effects on mice, and the former is more poisonous than the latter. |
| Keywords: | sophocarpine oxysophocarpine acute toxicity median lethal dose confidence interval |
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