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The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese Population
Authors:Hui Li   Cheng-Ye Wang   Jia-Xin Wang   Nelson Leung-Sang Tang   Liang Xie   Yuan-Ying Gong   Zhao Yang   Liang-You Xu   Qing-Peng Kong  Ya-Ping Zhang
Affiliation:(1) State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, PR, China;(2) Laboratory for Conservation and Utilization of Bio-resource & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, PR, China;(3) Graduate School of the Chinese Academy of Sciences, Beijing, 100049, PR, China;(4) KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, 650223, PR, China;(5) Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China;(6) Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, China;(7) People's Hospital of Dujiangyan, Dujiangyan, 611830, PR, China;(8) Dujiangyan Longevity Research Centre, Dujiangyan, 611830, PR, China
Abstract:

Background  

DC-SIGNR (also called CD209L) has been extensively studied on its role in host genetic predisposition to viral infection. In particular, variable number tandem repeat (VNTR) of the neck-region of DC-SIGNR is highly polymorphic and the polymorphism has been investigated for genetic predisposition to various infectious diseases, though conflicting results had been reported. As infection is a major cause of human death and a mechanism of natural selection, we hypothesized that VNTR polymorphism of DC-SIGNR might have an effect on human life span.
Keywords:
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