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| PCNA蛋白在胃癌组织中的表达及其与预后的关系 | |
| 引用本文： | 周志鹏,盛波,孙充兵,陈栋,张艳君. PCNA蛋白在胃癌组织中的表达及其与预后的关系[J]. 中国现代普通外科进展, 2011, 14(5): 340-343. DOI: 10.3969/j.issn.1009-9905.2011.05.003 |
| 作者姓名： | 周志鹏 盛波 孙充兵 陈栋 张艳君 |
| 作者单位： | 1. 中国人民解放军总医院,外科临床部,北京100853 2. 广东省江门市五邑中医院普通外科,广东江门,529000 3. 山东省潍坊市人民医院普通外科,山东潍坊,261041 4. 山东省临朐县人民医院普通外科,山东潍坊,262600 5. 中国人民解放军总医院,普通外科,北京100853 |
| 摘 要： | 目的：探讨PCNA蛋白在胃癌组织中的表达情况,并分析其与临床病理特征及预后的关系。方法：回顾性分析300例确诊并手术治疗的胃癌患者的病历资料,采用免疫组织化学SP法检测PCNA蛋白在胃癌组织及癌旁正常组织的表达,使用Kaplan-Meier法计算无复发生存率,评估PCNA蛋白与胃癌生物学特征及预后的关系。结果：癌旁正常组织中PCNA蛋白的阳性表达水平明显低于肿瘤组织（13.3%vs 36.7%,P〈0.05）。PCNA蛋白的表达与胃癌患者年龄、性别、肿瘤大小以及是否有远处转移等无明显相关性（P〉0.05）;而与病理组织的Lauren分型、肿瘤细胞的分化程度、是否有淋巴结转移以及TNM分期相关（P〈0.05）。Kaplan-Merier曲线显示,PCNA蛋白阳性表达患者的术后无复发生存率较阴性表达患者明显降低（P〈0.001）。结论：PCNA蛋白在胃癌组织中高表达,其高表达提示预后不良。 |
| 关 键 词： | 胃肿瘤 增殖细胞核抗原 预后 |
Expression of PCNA protein and its relationship with prognosis of gastric carcinoma |
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| ZHOU Zhi-peng,SHENG Bo,SUN Chong-bing,CHEN Dong,ZHANG Yan-jun. Expression of PCNA protein and its relationship with prognosis of gastric carcinoma[J]. Chinese Journal of Current Advances in General Surgery, 2011, 14(5): 340-343. DOI: 10.3969/j.issn.1009-9905.2011.05.003 | |
| Authors: | ZHOU Zhi-peng SHENG Bo SUN Chong-bing CHEN Dong ZHANG Yan-jun |
| Affiliation: | ZHOU Zhi-peng1,SHENG Bo2,SUN Chong-bing3,CHEN Dong4,ZHANG Yan-jun5 1Department of Surgery,5Department of General Surgery,General Hospital of PLA(Beijing 100853,China) 2Department of General Surgery,TCM Hospital of Wuyi,Jiangmen City(Jiangmen 529000,China) 3Department of General Surgery,People's Hospital of Weifang City(Weifang 261041,China) 4Department of General Surgery,Linqu Hospital of Weifang City(Weifang 262600,China) |
| Abstract: | Objective: To investigate the expression of proliferating cell nuclear antigen(PCNA)in gastric carcinoma and its relationship with clinicopathologic factors and prognosis of gastric carcinoma.Methods: Tissue samples from 300 cases with gastric carcinoma and 15 cases with normal gastric as control group were studied.The expression of PCNA protein was detected by SP immunohistochemistry.Results: The positive rate of PCNA protein in gastric carcinoma was significantly higher than that in normal gastric tissue(... |
| Keywords: | Stomach neoplasms·Proliferation cell nuclear antigen·Prognosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |