Sequences of four previously undescribed human T-cell receptor beta chain variable genes. |
| |
| Authors: | T Hansen E Qvigstad K E Lundin E Thorsby |
| |
| Affiliation: | Institute of Transplantation Immunology, National Hospital, Oslo, Norway. |
| |
| Abstract: | ![]()
T-cell receptor beta chain mRNA from 4 human T-lymphocyte clones was reverse transcribed, amplified by PCR, cloned in M13 and sequenced. Four hitherto undescribed variable genes were found. One of them (V beta-IW22) showed the highest homology (74.5%) to V beta 1. Two others (V beta-IW6 and V beta-IW10) belonged to the recently described V beta 21 family. The last gene (V beta-VW114) belonged to the V beta 9 family. However, the latter gene a is pseudogene because of an in-frame stop codon. |
| |
| Keywords: | |
|
|
