丁型肝炎病毒感染的血清流行病学观察

1987年4月至1988年10月间,本文应用酶联吸附法(EIA)对石家庄地区Ml例乙型肝炎病毒感染者进行了抗-HD的检测,共发现35例阳性,阳性率12.92%,其中男性阳性率14.06%(27/102),女性为10.13%(8/79),男女间差异无统计学意义(P>0.05),提示石家庄地区可能为丁型肝炎病毒感染的高发区.在这些人群中,慢性活动性肝炎、慢性迁延性肝炎和肝硬化的抗-HD阳性率明显高于HBsAg携带者,但三者相互间差异无统计学意义,表明合并或重香感染HDV对乙肝慢性化及肝硬化的形成具有重要的意义。本研究证明在乙型肝炎病毒感染人群中丁型肝炎病毐与年龄、性别、职业等因素关系不密切。

The Seroepidemiological Obervation on Hepatitis Delta Virus Infection

To assess the relationship between hepatitis delta virus (HDV) infection and HBV and reveal the distribution of HDV infection and the feature of epidemic, we collected 271 cases of HBV infected people in Shijiazhuang area and tested anti-HD with EIA from April 1987 to October 1988. This study found the prevalence of HDV infection was as high as 12.92% (35/271), and male prevalence of anti-HD was 14.06% (27/192) and female 10.13% (8/79), but there was no significance difference (P greater than 0.05). This suggested that the area of Shijiazhuan was a spot where HDV infection was high. Among these people, the positive rate of anti-HD in chronic active hepatitis, chronic persistent hepatitis and cirrhosis was much higher than that in HBsAg carriers. These finding indicated that HDV infection (coinfection and superinfection) was important in pathogenesis of chronic hepatitis B and in exacerbating liver disease to cirrhosis. This study confirmed that there was no significant difference between HDV infection and age, sex and occupation among HBV infected people.