103例出生缺陷的1：2配对病例对照调查

本文报告陕西省城固县1987年1~12月出生缺陷监测结果。在5 950例围产儿中,出生缺陷135例,发生率22.66‰。对其中103例作了病例对照调査、1:2配对,资料作了单因素和配合条件Logistic回归模型的多因素分析。结果表明:孕早期感冒发烧、孕母文盲、家庭先天疾患史、生殖道出血、孕期饮酒和近亲结婚六个因素是出生缺陷的危险因素。并对此进行了讨论。

1:2 Matched Case-Control Study of Congenital Deficiency of Newborn

Among 5959 perinatal newborn, 135 cases of congenital deficiency were detected. The frequency was 22.66 per 1,000 newborns. In order to explore possible factors related to congenital deficiency, for 103 cases a 1:2 matched case-control study was performed. Mantel-Haentel chi 2 test and conditional logistic regression model was used to identify factors which associated with the disease significantly in statistics. It was found that six factors, i.e. common cold and fever in the early stage of pregnancy, illiteracy of mother, family history of congenital disease, haemorrhage of genital tract, alcohol drinking and marriage within blood relatives, are risk factors related to congenital deficiency of newborn.