电压依赖性钾通道与肺动脉高压的研究进展

肺动脉高压是一种肺血流受限引起肺血管阻力和压力持续性增高，最终导致右心衰竭甚至死亡的综合征，病理生理学的改变主要为肺血管收缩、重塑及原位血栓的形成。近年研究表明，钾离子通道决定着肺动脉平滑肌细胞膜上的膜静息电位形成、调节血管紧张性及参与肺动脉平滑肌细胞的生长、增殖和凋亡。因此，钾通道调节血管收缩和调控肺动脉平滑肌细胞（Pulmonary artery smooth muscle cells, PASMCs）凋亡等方面发挥重要作用，具有抗肺动脉高压的作用，有望成为治疗肺动脉高压的新靶点。

Research progress in voltage-dependent potassium channels and pulmonary hypertension

Pulmonary hypertension is a syndrome where pulmonary vascular resistance and pressure increase continuously due to limited pulmonary blood flow, eventually leading to right heart failure and even death. Pathophysiological changes mainly include pulmonary vasoconstriction, remodeling, and in situ thrombosis. In recent years, studies have shown that potassium channels determine the resting potential of pulmonary artery smooth muscle cells （PASMCs）, regulate vascular tone, and are involved in the growth, proliferation, and apoptosis of PASMCs. Opening of potassium channels can inhibit vasoconstriction and induce apoptosis of PASMCs, thus reversing pulmonary hypertension. Therefore, potassium channel is expected to become a new target for the treatment of pulmonary hypertension.