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| 构建自动、智能及敏感度高的避暗实验检测系统 | |
| 引用本文： | 薛丹,陈善广,徐淑萍,石哲,李海清,殷泰晖,刘新民,李澎涛. 构建自动、智能及敏感度高的避暗实验检测系统[J]. 中国组织工程研究与临床康复, 2010, 14(15). DOI: 10.3969/j.issn.1673-8225.2010.15.028 |
| 作者姓名： | 薛丹 陈善广 徐淑萍 石哲 李海清 殷泰晖 刘新民 李澎涛 |
| 作者单位： | 1. 中国医学科学院北京协和医学院药用植物研究所,北京市100193;北京中医药大学基础医学院,北京市100029 2. 中国航天员中心,北京市,100094 3. 中国医学科学院北京协和医学院药用植物研究所,北京市,100193 4. 中国航天员中心,第十四研究室,北京市100094 5. 中国航天员中心,第十二研究室,北京市100094 6. 北京中医药大学东直门医院神经内科,北京市,100701 |
| 基金项目： | 国家科技支撑计划，国家科技重大专项 |
| 摘 要： | 背景:避暗法在认知功能障碍研究中应用广泛,但传统检测方法存在费时、信息量少、客观性差等问题.计算机、信息工程等现代科技的发展给构建新的实验检测方法提供了良好契机.目的:建立一种自动化、智能化、敏感程度高的避暗实验系统,用于动物的学习记忆研究.方法:采用图像处理、模式识别等技术提取动物在明暗室的活动信息,利用正常小鼠和东莨菪碱模型小鼠进行避暗实验,同时与传统检测结果进行比较.结果与结论:实验所用的检测系统提取的指标与传统检测结果吻合度高,结果科学客观.且明暗室时间、路程、明室近口区时间等新指标可能比经典指标更加敏感.说明此系统是一种新的自动化、智能化程度高,指标敏感性强的避暗实验检测系统. |
| 关 键 词： | 避暗 计算机 图像处理 小鼠 学习记忆 |
Establishment of a highly automated and intelligent experimental system of passive avoidance for mice |
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| Xue Dan,,Chen Shan-guang,Xu Shu-ping,Shi Zhe,Li Hai-qing,Yin Tai-hui,Liu Xin-min,Li Peng-tao Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences , Perking Union Medical College,Beijing ,China,School of Basic Medical Science,Beijing University of Chinese Medicine,Beijing ,Astronaut Center of China,Beijing ,the th Research Room of Astronaut Center of China,the th Research Room of Astronaut Center of China,Beijing .... Establishment of a highly automated and intelligent experimental system of passive avoidance for mice[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2010, 14(15). DOI: 10.3969/j.issn.1673-8225.2010.15.028 | |
| Authors: | Xue Dan Chen Shan-guang Xu Shu-ping Shi Zhe Li Hai-qing Yin Tai-hui Liu Xin-min Li Peng-tao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Perking Union Medical College Beijing China School of Basic Medical Science Beijing University of Chinese Medicine Beijing Astronaut Center of China Beijing the th Research Room of Astronaut Center of China the th Research Room of Astronaut Center of China Beijing ... |
| Affiliation: | Xue Dan1,2,Chen Shan-guang3,Xu Shu-ping1,Shi Zhe1,Li Hai-qing4,Yin Tai-hui5,Liu Xin-min1,Li Peng-tao6 1Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences , Perking Union Medical College,Beijing 100193,China,2School of Basic Medical Science,Beijing University of Chinese Medicine,Beijing 100029,3Astronaut Center of China,Beijing 100094,4the 14th Research Room of Astronaut Center of China,5the 12th Research Room of Astronaut Center of China,Beijing 1... |
| Abstract: | BACKGROUND:Widely used in cognitive dysfunction research,passive avoidance test was executed time consuming,less information and lack of objectivity in the traditional manner.The development of modern technology such as computer and information engineering is beneficial for inventing new detective methods.OBJECTIVE:To establish a highly automated and intelligent experimental system of passive avoidance for studying learning and memory in animal behavior pharmacology.METHODS:Image processing and pattern reco... |
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