阴茎海绵体平滑肌细胞间隙连接的研究进展

阴茎海绵体平滑肌的收缩能力在人类阴茎勃起中起重要作用。了解引发、维持和调节阴茎海绵体平滑肌张力的机制是进一步认识、诊断和治疗阴茎勃起功能障碍的前提。尽管如此 ,在生理学上 ,想认识内源性和外源性血管调节剂如何作用于个体阴茎海绵体平滑肌细胞的确切机制 ,以及在成对的阴茎海绵体中 ,这些信号如何在各个实质细胞中传递的过程仍较困难。本文目的 :①综述目前所了解的阴茎海绵体平滑肌张力在细胞和分子水平的调节机制 ;②综述各种方法在间隙通道研究中的应用

Intercellular Gap Junctions in Corporal Smooth Muscle

The contractility of corporal smooth muscle plays a critical role in human penile erectile process. Understanding the initiation, maintenance and modulation of corporal smooth muscle tone is a prequisite to improve understanding, diagnosis and treatment of erectile dysfunction. Despite this fact, indentification of both the precise mechanistic basis by which various agents exert their effects on individual corporal smooth muscle cells, moreover, the process by which these signals are spread among the diverse array of parenchymal cells in the paired corporal, remain somewhat of a physiological enigma. Therefore, this article aims at: 1. to review current knowledge of the regulation of corporal smooth muscle tone at the cellular and molecular level; 2. to review various methods used in the study of gap junction channel.