乳舒片对大鼠乳腺增生及激素分泌的影响

目的：研究乳舒片对大鼠乳腺增生及激素分泌的影响。方法：大鼠隔日ip苯甲酸雌二醇，连续6周，复制大鼠乳腺增生模型。应用乳舒片（高、中、低3个剂量组）处理模型大鼠4周，测定第1、2对乳头高度及直径，采血测定血清中雌激素和孕激素水平，取胸前第1、2对乳房乳腺、胸腺、脾脏、子宫卵巢称重，计算脏器系数；并将乳腺、子宫及卵巢置于10％甲醛溶液中固定，做病理组织检查。结果：乳舒片可改善乳腺增生病大鼠乳腺的组织形态学结构，缩小乳头大小和乳腺体积，减少乳腺小叶腺泡数、腺泡腔、分泌物，并可使血清雌激素水平降低（P＜0.01）。结论：乳舒片可能通过调节乳腺增生大鼠的性激素水平，改善增生乳腺的形态学变化而有效地对抗雌激素引起的大鼠乳腺增生。

Effect of Rushu Tablet on hyperplasia of mammary glands and hormones in rats

Objective: To study the effects of Rushu Tablet on estrogen, progesterone and pathological change of mammary tissue in hyperplasia of mammary gland and hormone of rats. Methods: The hyperplasia of mammary gland model was induced by Estradiol benzoate intraperitoneal injection in SD female rats once every two days for six weeks. The model rats were treated with low, middle, and high dosages of Rushu Tablet, respectively. To kill all rats after 4 weeks, determinate the level of estrogen, weight organs, and organ coefficient, and observe the tissue of mammary glands. Results: Rushu Tablet could be used for improving the morphological structure of mammary, shortening the papilla and lobule of mammary gland size, diminishing alveoli, Acinar cavity and secretion, reducing the level of estrogen in hyperplasia mammary gland rats (P < 0.05). Conclusion: Rushu Tablet could inhibit mammary gland hyperplasia whose mechanism may base on the regulating of hormone in hyperplasia of mammary gland rats.