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| 由血管紧张素(1-7)重新认识RAS系统 | |
| 引用本文： | 李广平,张承宗. 由血管紧张素(1-7)重新认识RAS系统[J]. 中国心血管杂志, 2005, 10(1): 60-62 |
| 作者姓名： | 李广平 张承宗 |
| 作者单位： | 天津医科大学第二医院心脏科天津心脏病研究所,天津,300211 |
| 摘 要： | 对血管紧张素 (1- 7)的研究使我们对肾素 -血管紧张素系统 (RAS)有了更全面的认识。血管紧张素 (1-7)通过特异性的受体发挥生理作用。血管紧张素Ⅰ和血管紧张素Ⅱ经过特异的肽链内切酶变为血管紧张素 (1 -7) ,再经血管紧张素转换酶作用降解为无活性的血管紧张素 (1- 5 )。血管紧张素 (1- 7)具有抗增殖、扩张血管、抗氧化应激及促进纤溶的作用。 |
| 关 键 词： | 肾素血管紧张素系统 血管紧张素(1-7) |
| 文章编号： | 1007-5410(2005)01-0060-03 |
| 修稿时间： | 2004-04-13 |
Angiotensin(1-7) and renin-angiotensin system |
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| LI Guang-ping,ZHANG Cheng-zong. Angiotensin(1-7) and renin-angiotensin system[J]. Chinese Journal of Cardiovascular Medicine, 2005, 10(1): 60-62 | |
| Authors: | LI Guang-ping ZHANG Cheng-zong |
| Affiliation: | LI Guang-ping,ZHANG Cheng-zong. Department of Cardiology,Second Hospital of Tianjin Medical University,Tianjin 300211,China |
| Abstract: | The recognition of rennin-angiotensin system (RAS) has been developed as the studies of angiotensin(1-7), a new member of RAS. Angiotensin(1-7) plays its physiological roles through a specific receptor. Angiotensin(1-7) was produced from angiotensinⅠ and angiotensin Ⅱ by tissue peptidases, including neutral endopeptidase (neprilysin), thimet oligopeptidase, prolyl-carboxypeptidase, and prolyl-endopeptidase. And then angiotensin(1-7) was degenerated by angiotensin converting enzyme. Angiotensin(1-7)has the effects of vasodilation and anti-proliferation. |
| Keywords: | Angiotensin(1-7) Renin-angiotensin system |
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