表皮样囊肿癌变临床病理分析

【摘要】目的： 探讨表皮样囊肿癌变的临床特点、病理形态、免疫组化及预后等。方法： 收集我科6例表皮样囊肿癌变资料,分析其临床特点，观察病理形态及免疫组化表型，通过随访了解其预后，并结合相关文献等进行分析。结果： 临床特点：均为局部包块，行扩大切除，随访一年，无复发和转移。病理检查：为不整形肿块，囊性,内为豆渣样物。镜检：囊内为变性层状角质物，囊壁衬覆鳞状上皮，癌变区鳞状上皮呈巢团状间质浸润。病理诊断：表皮样囊肿癌变为鳞状细胞癌。免疫表型：6例癌变鳞状细胞CK5/6、P63阳性。结论： 表皮样囊肿癌变非常少见，诊断主要靠常规病理切片确诊，免疫组化标记协助诊断，局部适当扩大切除为首选，其恶性程度较低，预后较好。

Clinical and Pathological Features of Canceration of Epidermoid Cyst

[abstract] Objective: To study and research the clinical pathologic features ,immunohistochemistry and prognosis of epidermoid cyst with cancerous changes. Methods: Six cases of epidermoid cyst with cancerous changes were studied to research the clinical pathologic features , immunohistochemistic expression and evaluate the prognosis by follow-up visits .Results: Clinical features: six cases were all local bag piece and expanded resection. Follow-up of one year, No one have recurrence and metastasis. Pathological examination: they were all for not plastic masses and cystic,something like bean curd were in the cyst. Microscopic examination: These cysts lined by squamous epithelium and they presented invasive growth. Pathological diagnosis: Epidermoid cyst canceration of squamous cell carcinoma. Immunophenotype: Squamous cell cancer of six cases were positive expressions of CK5/6 and P63. Conclusion: Epidermoid cyst with cancerous changes are quite rare.Diagnosis of the tumor relies largely on histopathology.Immunohistochemical markers assist the diagnosis. Local appropriately expanded resection is preferred. The malignant degree is low and prognosis is good.