Peak-ratio interference pattern analysis in the detection of neuromuscular disorders |
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| Institution: | 1. Ludwig Boltzmann Institute for Research in Epilepsy and Neuromuscular Disorders, Postfach 348, 1180 Vienna, Austria;2. Department of Clinical Neurophysiology, Gentofte HospitallUniversity of Copenhagen, Copenhagen, Denmark;1. Perinatal Diabetes Research Center, Department of Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_UNESP, Botucatu, São Paulo, Brazil;2. Cellular and Molecular Physiology Laboratory, Division of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile;3. Department of Physiology, Faculty of Pharmacy, Universidad De Sevilla, Seville, Spain;4. University of Queensland Centre for Clinical Research, Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, Queensland, Australia;1. Department of Chemical Engineering, Materials Environment & UdR INSTM, Sapienza-Università di Roma, Roma, Italy;2. Department of Civil and Environmental Engineering & UdR INSTM, University of Perugia, Terni, Italy;1. Department of Hepatobiliary Pancreatic Surgery, China-Japan Union Hospital of Jilin University, No.126, Xiantan Street, Changchun, 130033, China;2. Department of Stomatology, China-Japan Union Hospital of Jilin University, No.126, Xiantan Street, Changchun, 130033, China;3. Department of Traditional Chinese Medicine, China-Japan Union Hospital of Jilin University, No.126, Xiantan Street, Changchun, 130033, China;4. Department of Breast Surgery, China-Japan Union Hospital of Jilin University, No.126, Xiantan Street, Changchun, 130033, China;5. Department of Pathology, China-Japan Union Hospital of Jilin University, No.126, Xiantan Street, Changchun, 130033, China;6. Department of Anesthesiology, China-Japan Union Hospital of Jilin University, No.126, Xiantan Street, Changchun, 130033, China;1. GRC 01, GREEN - groupe de recherche clinique en neuro-urologie, hôpital Tenon, Sorbonne université, AP–HP, 75020 Paris, France;2. Service de neuro-urologie, hôpital Tenon, AP–HP, 4, rue de la Chine, 75020 Paris, France |
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| Abstract: | Peak-ratio interference pattern analysis (peak-ratio method) is said to have a high sensitivity and to be independent of sex and age. This study was carried out to prove or disprove these findings. The peak-ratio method and qualitative motor unit action potential (MUAP) analysis were applied to the right brachial biceps and anterior tibial muscles of 44 healthy subjects, aged 23–87 years, 25 neuropathy patients, aged 21–83 years, and 29 myopathy patients, aged 19–70 years. Peak-ratio parameters were independent of sex and age. They tended to be lower in the anterior tibial muscle than in the brachial biceps muscle. Neuropathy patients typically showed decreased peak-ratio, short time intervals and increased amplitude/turn. Myopathy patients typically showed increased peak-ratio, turns/s and short time intervals. The sensitivity of the peak-ratio method was 72% for neuropathy patients and 59% for myopathy patients. The sensitivity of the peak-ratio method was similar to that of the MUAP analysis in neuropathy patients and higher than that of the MUAP analysis in myopathy patients. The specificity of the peak-ratio method was 80%. The peak-ratio method proved to be a valuable, supplementary electromyographic tool for the detection of neuromuscular disorders. |
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