Genetic association study between α 1‐antichymotrypsin polymorphism and Alzheimer disease in Chinese Han population |
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| Authors: | Sanduo Jiang Mingyuan Zhang Sicui Lin Yipin Qian Xiaodong Wu Dongxiang Wang Tongguan Jin Niufan Gu |
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| Affiliation: | 1. Department of Genetics, Shanghai Institute of Mental Health, Shanghai, China;2. Shanghai Mental Health Center, Shanghai, China |
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| Abstract: | ![]()
We investigated a common signal peptide polymorphism in the α 1‐antichymotrypsin (ACT) gene in 125 sporadic Alzheimer disease (AD) patients and 141 healthy control subjects in Chinese Han population. We found no significant difference in the distribution of ACT polymorphism between AD cases and controls, and failed to detect any effects of ACT genotypes associated with AD. Thus, our data do not support the involvement of ACT polymorphism in the risk of AD in Chinese Han population. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:133–135, 2000. © 2000 Wiley‐Liss, Inc. |
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| Keywords: | α 1‐antichymotrypsin apolipoprotein E Alzheimer disease |
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