| Mage-A3抗原肽负载DC过继免疫治疗乳腺癌的实验研究 |
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| 引用本文： | 马全,武正炎,查小明,郑伟. Mage-A3抗原肽负载DC过继免疫治疗乳腺癌的实验研究[J]. 实用临床医药杂志, 2006, 10(3): 2-4 |
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| 作者姓名： | 马全 武正炎 查小明 郑伟 |
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| 作者单位： | 南京医科大学第一附属医院,普外科,江苏,南京,210029;南京医科大学第一附属医院,普外科,江苏,南京,210029;南京医科大学第一附属医院,普外科,江苏,南京,210029;南京医科大学第一附属医院,普外科,江苏,南京,210029 |
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| 基金项目： | 南京医科大学创新基金(CX200003)，江苏省医学重点学科江苏省人民医院普外科开放课题(wk200235) |
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| 摘 要： | 目的研究Mage-A3抗原肽负载DC对小鼠乳腺癌的治疗作用。方法体外培养小鼠骨髓来源的DC,并经孵育携带Mage-A3抗原肽,在乳腺癌小鼠模型中进行试验性治疗。结果治疗组与对照组肿瘤体积差异显著(P<0.05),冻融上清负载组和Mage-A3抗原肽负载组没有显著性差异。结论负载Mage-A3抗原肽的DC可以诱导特异性的CTL免疫应答,对小鼠乳腺癌有良好的免疫治疗作用。
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| 关 键 词： | 抗原 Mage-A3 树突状细胞 乳腺癌 细胞毒性T淋巴细胞 |
| 文章编号： | 1672-2353(2006)02-0002-03 |
| 修稿时间： | 2005-10-26 |
IMMUNOTHERAPY OF DENDRITIC CELLS LOADED WITH THE PEPTIDE DERIVED FROM Mage-A3 ON MICE BREAST CANCER |
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| MA Quan,WU Zheng-yan,ZHA Xiao-ming,ZHENG Wei. IMMUNOTHERAPY OF DENDRITIC CELLS LOADED WITH THE PEPTIDE DERIVED FROM Mage-A3 ON MICE BREAST CANCER[J]. Journal of Clinical Medicine in Practice, 2006, 10(3): 2-4 |
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| Authors: | MA Quan WU Zheng-yan ZHA Xiao-ming ZHENG Wei |
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| Abstract: | Objectve To investigate the experimental immunotherapy of the dendritic cells(DCs) loaded with the peptide derived from Mage-A_3 on mice breast cancer model.Methods DCs were induced from mice bone marrow.The DCs pulsed by Mage-A_3 peptide(DC-P) were used to on mice breast cancer model.Results There was significant difference between the therapy group and the empty control group,but there was no significant difference between the group of DC-P and the group of DC loaded with the TM40D lysates group.Conlusion The DC loaded with Mage-A_3 peptide could elicit specific CTL responses in breast cancer.The immunotherapy based on DCs loaded with Mage-A_3 peptide is a promising biology therapy. |
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| Keywords: | antigen Mage-A_3 dendritic cells cancer cytotoxic T lymphocytes |
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