针药并用治疗强直性脊柱炎伴骨量减少与骨质疏松的临床研究

目的:观察“双固一通”针法及抗骨质疏松药物对强直性脊柱炎伴骨量减少、骨质疏松患者的治疗作用及其对血沉、CRP、骨密度的调节作用.方法:将强直性脊柱炎伴骨量减少、骨质疏松患者90例随机分为3组:治疗组、电针组和对照组,每组30例.治疗组予针药结合,电针组单纯予电针治疗,对照组单纯予西药.治疗12周.结果:治疗组总有效率为93.33％(95％ CI=77.9％～99.2％),电针组为76.67％(95％ CI=57.7％～90.1％),对照组为80.00(95％ CI =61.4％～92.3％)；与电针组比较,治疗组综合疗效有显著性差异(u =2.017 8,P=0.043 8)；各组治疗后主要症状总积分参数比较,治疗组优于电针组(u =2.140 8,P=0.032 5)；治疗后各组BASFI积分参数比较,治疗组优于电针组(u=3.750 2,P＜0.01)、对照组(u =2.158 3,P＜0.05)；各组ESR、CRP参数比较,治疗组优于电针组(t=-7.081 4,P＜0.01；t=-2.444 2,P＜0.05)、对照组(t=-6.577 8、2.825 4,P＜0.01)；治疗组治疗后骨密度提高,明显优于对照组(u =2.122 5,P＜0.05).结论:针药并用治疗强直性脊柱炎伴骨量减少、骨质疏松患者疗效优于电针组,其收益为OR =0.23 (95％ CI =0.04 ～ 1.24),NNT =6(95％CI=2.88～76.92)；能改善临床症状,提高生存质量,提高骨密度,降低疾病活动度.

Clinical Research of Combination of Acupuncture and Traditional Chinese Medicine on Ankylosing Spondylitis with Osteopenia and Osteoporosis