动脉粥样斑块破裂的研究进展

急性冠状动脉综合征发生的主要病理生理机制系粥样斑块破裂。因此 ,研究斑块破裂的机制及探索稳定斑块的方法具有重要临床意义。本文综合现有文献 ,就粥样斑块的形成、分类及其新的认识 ,斑块破裂的方式 ,斑块破裂的影响因素 ,斑块破裂的模型复制及其预测方法 ,斑块破裂的防治现状作一概述 ,并提出急性冠状动脉综合征以稳定易破斑块为重点。

Progress in research on arterial atherosclerotic plaque rupture

The principal pathophysiological mechanism of acute ischemic coronary syndrome(AICS) is atherosclerotic plaque rupture.It is,therefore,clinically very important to study the underlying cause of plaque rupture and to explore the possible method for stabilizing plaque.In the present article,the formation,classification and new concept of plaque,the possible way and risk factors of atherosclerotic plaque rupture,a new animal model of atherosclerotic plaque rupture,the predicting means and therapeutic status of plaque rupture are reviewed.The future direction for study on atherosclerotic plaque should be concentrated on stabilizing the vulnerable plaque.