长托宁代替阿托品救治急性有机磷农药中毒的临床疗效

目的探讨长托宁(盐酸戊乙奎醚)代替阿托品救治急性有机磷中毒临床效果。方法将76例急性有机磷中毒患者随机分为阿托品组与长托宁组各38例,在常规治疗基础上阿托品组联用阿托品、长托宁组联用长托宁治疗,观察患者用药后机体各项指标及预后。结果长托宁组与阿托品组比较,用药次数、中毒症状消失时间、CHE恢复时间及住院时间明显减少(或缩短),组间比较存在统计学差异(p<0.05);阿托品组死亡率5.26%,长托宁组死亡率2.63%,组间比较无统计学差异(p>0.05);两组患者视力模糊、心率增快及尿潴留发生率间比较存在统计学差异(p<0.05)。结论抢救有机磷中毒,长托宁与阿托品均能起到较好治疗效果,并且长托宁不良反应低,可代替阿托品用于治疗有机磷中毒。

ANALYSIS OF THE CLINICAL EFFECT OF PENEHYCLIDINE INSTEAD OF ATROPINE IN EMERGENCY TREATMENT OF ACUTE ORGANOPHOSPHORUS PESTICIDE POISONING

Objective To explore the clinical effect of changtuoning(penehyclidine hydrochloride injection) instead of atropine in emergency treatment of acute organophosphorus pesticide poisoning. Methods 76 cases of acute organophosphate poisoning were randomly divided into atropine group and changtuoning group,each of 38 cases.On the basis of conventional therapy,patients of atropine group associated with atropine,changtuoning group associated with changtuoning treatment,observe patients after treatment,the body indicators and outcomes. Results Comparing with atropine group,the times of medication,poisoning symptoms disappear time,CHE recovery time and the hospital stay time of changtuoning group were obviously decreased,with the differences of statistic significance(p<0.05);the mortality rate of atropine group was 5.26%,and that of changtuoning group was 2.63%,there was no significant difference between the two groups(p>0.05);but the rate of blurred vision,increased heart rate,and urinary retention between the two groups there were significant differences(p<0.05). Conclusion Both changtuoning and atropine can achieve better effect in emergency treatment of acute organophosphorus poisoning,but changtuoning has less adverse reaction so it can replace atropine in this treatment.