外周血炎性细胞因子与类风湿关节炎

背景：由滑膜细胞、单核/巨噬细胞以及淋巴细胞等产生的炎性细胞因子在类风湿关节炎的发病中发挥着重要作用。白细胞介素17是近年来发现的一个炎性细胞因子,与很多自身免疫性疾病有关。目的：观察类风湿关节炎患者血清中辅助性T细胞17相关的白细胞介素17水平及其与红细胞沉降率、C-反应蛋白、疾病活动性的相关性。方法：纳入2008年1月至2009年12月在解放军成都军区总医院就诊的符合1987年美国风湿病协会修订的类风湿关节炎分类标准的类风湿关节炎患者79例作为病例组,同时选取同时期性别、年龄与病例组相匹配的50名健康体检者作为对照组。根据28处关节疾病活动性评分指数将病例组分为活动组49例和稳定组30例。结果与结论：ELISA检测结果显示,类风湿关节炎患者血清白细胞介素17水平明显高于对照组（P〈0.01）,且活动期患者的白细胞介素17水平高于稳定期患者（P〈0.01）。Pearson相关分析结果显示,活动期类风湿关节炎患者血清中白细胞介素17水平与红细胞沉降率、C-反应蛋白、28处关节疾病活动性评分指数均呈正相关（r=0.459,0.379,0.455;P〈0.05）。说明白细胞介素17参与了类风湿关节炎的炎症反应,与红细胞沉降率、C-反应蛋白、28处关节疾病活动性评分指数等同样能反映病情的活动性。

Correlation between peripheral blood inflammatory cytokines and rheumatoid arthritis

BACKGROUND：The inflammatory cytokines,produced by synovial cells,monocytes/macrophages and lymphocytes,play a major role in the pathogenesis of rheumatoid arthritis.Interleukin-17,a recently found inflammatory cytokine,associates with many autoimmune diseases.OBJECTIVE：To investigate the correlation between the levels of interleukin 17 related to Th17 cells in serum of rheumatoid arthritis patients and other laboratory markers such as erythrocyte sedimentation rate,C reactive protein and disease activity.METHODS：Seventy-nine patients with rheumatoid arthritis which line with classification criteria of rheumatoid arthritis revised by American Rheumatism Association in 1987 were selected from General Hospital of Chengdu Military Command（2008-01/2009-12）,and the 79 patients were regarded as the experimental group;meanwhile,50 healthy subjects who had the same gender and age with the experimental group were regarded as the control group.The experimental group was divided into activity group（n=49）and stable group（n=30）according the disease activity score in 28 joints.RESULTS AND CONCLUSION：Enzyme linked immunosorbent assay results showed that the level of interleukin 17 in peripheral blood of rheumatoid arthritis patients was significantly higher than that in the control group（P0.01）,and the level of interleukin 17 in the activity group was higher than that in the stable group（P0.01）.Pearson correlation analysis showed there was a positive correlation between interleukin 17 and erythrocyte sedimentation rate,C reactive protein,disease activity score in 28 joints in rheumatoid arthritis patients with active disease（r=0.459,0.379,0.455;P0.05）.Interleukin-17 was involved in the inflammatory response of rheumatoid arthritis,and it could also reflect disease activity just as the erythrocyte sedimentation rate and C-reactive protein,28 joint disease activity score index do.